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Sepiatec Supercritical Fluid Chromatography

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Overview

Sepiatec preparative Supercritical Fluid Chromatography (SFC) technology

Sepiatec designs compact and  very easy to use preparative SFC systems featuring an Integrated computer with a  TFT touch-screen placed in an ergonomically favorable position on the front of the unit and a new gas-liquid separation technology.

The Prep SFC 100 is a compact benchtop unit and an ideal upgrade path for older prep SFC systems that need replacement.

The Prep SFC 360 system represents a powerful solution for preparative separations by means of supercritical fluid chromatography. The unit has been designed for flow rates of up to 360 ml of supercritical fluid per minute. Depending on the modifier portion, even up to 600 ml/min may be achieved.

Preparative Supercritical Fluid Chromatography (pSFC)

As an environment-friendly approach to purification applications, pSFC is being used routinely for an increasing number of applications.

During the recent years SFC has gained acceptance in drug discovery for high-throughput purification of enantiomers. Hence, pSFC replaces preparative HPLC (pHPLC) as major technology for chiral separations in many pharmaceutical companies. Preparative SFC excels not only at separating and purifying chiral compounds but is also powerful for achiral separations and can be implemented in most steps of drug discovery. It may offer potential advantages over pHPLC for purity upgrading of active pharmaceutical ingredients or drug intermediates, impurity isolation and non-aqueous purification.

The use of pSFC as an alternative option to pHPLC receives also a growing interest for natural products, environmental (pesticides) and petroleum (biofuels) applications.

Sepiatec Prep SFC 100 system
A compact benchtop unit designed for preparative separation using supercritical fluid chromatography. Separation columns with inner diameters between 20 and 30 mm and a length of up to 250 mm can be used.

Sepiatec Prep SFC 360 system
The system represents a powerful solution for preparative separations by means of supercritical fluid chromatography. Separation columns with inner diameters between 25 and 50 mm and a length of up to 800 mm can be used.

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Articles

Preparative Supercritical Fluid Chromatography (pSFC)

As an environment-friendly approach to purification applications, pSFC is being used routinely for an increasing number of applications.

During the recent years SFC has gained acceptance in drug discovery for high-throughput purification of enantiomers. Hence, pSFC replaces preparative HPLC (pHPLC) as major technology for chiral separations in many pharmaceutical companies. Preparative SFC excels not only at separating and purifying chiral compounds but is also powerful for achiral separations and can be implemented in most steps of drug discovery. It may offer potential advantages over pHPLC for purity upgrading of active pharmaceutical ingredients or drug intermediates, impurity isolation and non-aqueous purification.

The use of pSFC as an alternative option to pHPLC receives also a growing interest for natural products, environmental (pesticides) and petroleum (biofuels) applications.

Literature

Sepiatec Prep SFC 100 system
A compact benchtop unit designed for preparative separation using supercritical fluid chromatography. Separation columns with inner diameters between 20 and 30 mm and a length of up to 250 mm can be used.

Sepiatec PREP SFC 360 system
Date of creation: 
4 November 2015
Library code: 
10393