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Cleaning in Place (CIP) testing

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Overview

Cleaning in Place (CIP) testing

The CIP process is aimed at removing any residual substances in manufacturing facilities and equipment (tanks, vessels, pipework) in various processing industries such as the pharmaceutical area. The CIP efficiency is critical to the overall production quality and must meet strict regulations while minimizing downtime between product runs or product changeover.

Teledyne Tekmar Total Organic Carbon (TOC) analyzers have found wide acceptance in the pharmaceutical and biotechnology industry to assist in the validation cleaning procedures, especially clean-in-place (CIP). TOC concentration levels can be used to track the success of these cleaning procedures.

Detection selection for TOC analysis, analytical considerations for cleaning validation and purified water testing
In this application, a comparison of two commonly used techniques, Non-Dispersive Infrared (NDIR) and Membrane Conductivity, will be given based on sample matrices.

Introduction to the Teledyne Tekmar Fusion TOC Analyzer
Teledyne Tekmar introduces its fifth generation Total Organic Carbon (TOC) UV/Persulfate analyzer, the Fusion.

Teledyne Tekmar general brochure
This brochure introduces Tekmar's instrumentation for VOC, SVOC and TOC analysis.

Cleaning in Place (CIP) testing by e-nose
Showing fast analysis time (less than 2 minutes per sample), high measurement repeatability and sensitivity, the Alpha MOS HERACLES E-Nose analyzer offers a reliable analytical method to ensure cleaning efficiency in controlled pharmaceutical environments.

Alpha MOS HERACLES Flash Gas Chromatography Electronic Nose
The HERACLES II is the most powerful and flexible electronic nose. This all-in-one instrument, both electronic nose and ultra fast gas chromatograph, performs overall odor profiling and chemical composition analysis in one run.

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Application notes

Detection selection for TOC analysis, analytical considerations for cleaning validation and purified water testing
In this application, a comparison of two commonly used techniques, Non-Dispersive Infrared (NDIR) and Membrane Conductivity, will be given based on sample matrices.

Date of creation: 
19 November 2015
Library code: 
10430
Literature

Introduction to the Teledyne Tekmar Fusion TOC Analyzer
Teledyne Tekmar introduces its fifth generation Total Organic Carbon (TOC) UV/Persulfate analyzer, the Fusion.

Teledyne Tekmar general brochure
Date of creation: 
9 March 2017
Library code: 
10785
Alpha MOS HERACLES Flash Gas Chromatography Electronic Nose
Date of creation: 
17 October 2015
Library code: 
10288