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Preparative Supercritical Fluid Chromatography (pSFC)

As an environment-friendly approach to purification applications, pSFC is being used routinely for an increasing number of applications.

During the recent years SFC has gained acceptance in drug discovery for high-throughput purification of enantiomers. Hence, pSFC replaces preparative HPLC (pHPLC) as major technology for chiral separations in many pharmaceutical companies. Preparative SFC excels not only at separating and purifying chiral compounds but is also powerful for achiral separations and can be implemented in most steps of drug discovery. It may offer potential advantages over pHPLC for purity upgrading of active pharmaceutical ingredients or drug intermediates, impurity isolation and non-aqueous purification.

The use of pSFC as an alternative option to pHPLC receives also a growing interest for natural products, environmental (pesticides) and petroleum (biofuels) applications.

Articles

Preparative Supercritical Fluid Chromatography (pSFC)

As an environment-friendly approach to purification applications, pSFC is being used routinely for an increasing number of applications.

During the recent years SFC has gained acceptance in drug discovery for high-throughput purification of enantiomers. Hence, pSFC replaces preparative HPLC (pHPLC) as major technology for chiral separations in many pharmaceutical companies. Preparative SFC excels not only at separating and purifying chiral compounds but is also powerful for achiral separations and can be implemented in most steps of drug discovery. It may offer potential advantages over pHPLC for purity upgrading of active pharmaceutical ingredients or drug intermediates, impurity isolation and non-aqueous purification.

The use of pSFC as an alternative option to pHPLC receives also a growing interest for natural products, environmental (pesticides) and petroleum (biofuels) applications.

Application notes

SFC measurement of fatty acid methyl esters and triglycerides in biodiesel fuel with charged aerosol detector
In this application, Jasco applied Supercritical Fluid Chromatography (SFC) coupled with CAD to an analysis of biodiesel fuel.

Separation of basic drugs by Supercritical Fluid Chromatography
Date of creation: 
7 July 2017
Library code: 
11043
Determination of olefin content of gasoline by SFC
Date of creation: 
7 July 2017
Library code: 
11041
Determination of non-aromatic and aromatic hydrocarbon contents of diesel fuels by SFC
Date of creation: 
7 July 2017
Library code: 
11049
Preparative purification of flavanone by semi-preparative UFC system and Cyclone Separator-87 (CS-87)
Date of creation: 
28 June 2017
Library code: 
11039
Investigation of chiral separation conditions of cetirizine by UFC methods scouting system
Date of creation: 
28 June 2017
Library code: 
11038
Investigation of chiral separation conditions of zopiclone by UFC Methods Scouting System
Date of creation: 
28 June 2017
Library code: 
11037
Investigation of chiral separation conditions of bupivacaine by UFC methods scouting system
Date of creation: 
28 June 2017
Library code: 
11036
Investigation of chiral separation conditions of omeprazole by unified fluid chromatography methods scouting system
Date of creation: 
28 June 2017
Library code: 
11035
Investigation of chiral separation conditions of warfarine by UFC Methods Scouting System
Date of creation: 
28 June 2017
Library code: 
11034
Literature
Sepax Supercritical Fluid Chromatography (SFC) columns
Date of creation: 
20 July 2017
Library code: 
11110