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Cleaning validation

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Cleaning in Place (CIP) testing

The CIP process is aimed at removing any residual substances in manufacturing facilities and equipment (tanks, vessels, pipework) in various processing industries such as the pharmaceutical area. The CIP efficiency is critical to the overall production quality and must meet strict regulations while minimizing downtime between product runs or product changeover.

Teledyne Tekmar Total Organic Carbon (TOC) analyzers have found wide acceptance in the pharmaceutical and biotechnology industry to assist in the validation cleaning procedures, especially clean-in-place (CIP). TOC concentration levels can be used to track the success of these cleaning procedures.

Cleaning in Place (CIP) testing by e-nose
Showing fast analysis time (less than 2 minutes per sample), high measurement repeatability and sensitivity, the Alpha MOS HERACLES E-Nose analyzer offers a reliable analytical method to ensure cleaning efficiency in controlled pharmaceutical environments.

Alpha MOS HERACLES flash gas chromatography electronic nose
The HERACLES II is the most powerful and flexible electronic nose. This all-in-one instrument, both electronic nose and ultra fast gas chromatograph, performs overall odor profiling and chemical composition analysis in one run.

Application notes
Date of creation: 
19 November 2015
Library code: 
Alpha MOS HERACLES flash gas chromatography electronic nose
Date of creation: 
17 October 2015
Library code: