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VICI DBS analytical gas generators
VICI DBS generators are specifically designed to meet the stringent gas requirements for all the leading GC and LC/MS instrument manufactures. Gas generators offer a safe, convenient and cost effective alternative to gas cylinders and dewars. A VICI DBS generator provides a dependable, easy to use and on-demand supply of ultra high purity gas.

Biotage industrial product portfolio
The Biotage portfolio of industrial scale products have a proven track record of successful applications and use in scale-up projects. The industrial product range can support the discovery, development and manufacturing of customer pharmaceutical and biotechnology products, from pre-clinical, phase I, II and III to small scale commercial operations.

Metal scavengers in process chemistry
Metal scavengers were first investigated for contamination by independently confirmed ICP metal analysis methods. Additionally, these scavengers were extracted in a range of common solvents in order to show extractable and leachable levels. A metal scavenging reaction comparing API product yield, purity and also metal removal using metal scavengers was compared to corresponding carbon methods.

Biotage ISOLUTE Si Trisamine metal scavenger
The Biotage ISOLUTE Si-Trisamine is a silica bound equivalent of a trisamine base and can scavenge a variety of electrophiles, including aldehydes, acid chlorides, sulfonyl chlorides, isocyanates, isothiocyanates and heavy metal ions such as Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Pb+2, Ru+2 and Zn2+. Si-Trisamine has a number of uses, it is a very powerful scavenger of transition metals and can also be used as a work-up tool to remove electrophiles or acids in either batch or flow-mode (cartridge) following traditional reflux heated or microwave synthesized reactions.

Biotage MP-TMT palladium scavenger
The Biotage MP-TMT is a macroporous polystyrene-bound trimercaptotriazine, a resin bound equivalent of 2,4,6-trimercaptotriazine (TMT). MP-TMT scavengers residual palladium from palladium catalyzed reactions and has also shown to remove other metals. The MP-base copolymer has been designed to yield a robust, low swelling material, which makes it ideal for restricted volume environments. Its unique pore structure provides greater access to the reactive sites resulting in faster reactions and higher recoveries.

Ruthenium scavenging applications
This study presents the use and applications of a convenient metal scavenging kit in a ruthenium metal removal process. The aim was to combine classic Grubbs chemistry with the concept of metal scavenging, to demonstrate how classical synthetic chemistry may be adapted to meet modern-day guidance on elemental impurities in the pharmaceutical industry.

Developing a scalable metals removal process using metal scavengers
This application note demonstrates the practical application of metal scavenging in the removal of palladium from a model active pharmaceutical ingredient (API).

Metal mitigation, extractables and regulatory perspectives
Metal scavengers were first investigated for inherent metals content by ICP analysis methods. Then, these scavengers were extracted in a range of common solvents in order to show extractable/leachable levels. Lastly, an example metal scavenging mitigation step is demonstrated, looking at the corresponding API mass yield, purity and also metals data.

Biotage metal scavenger user guide
This user guide gives useful information on the Biotage metal scavengers, including: case studies, methods and advantages of the metal scavengers. It has selection guides to help the user choose the right product for their needs.

Biotage ISOLUTE Si-TMT metal scavenger
The Biotage ISOLUTE Si-TMT is the silica bound equivalent of 2,4,6-trimer- captotriazine (TMT). Si-TMT has been shown to efficiently scavenge residual palladium from palladium-catalyzed reactions. The function group in Si-TMT is attached to a bioanalytical grade silica platform, thus the use of this material does not introduce impurities to the reaction system. There are numerous advantages of functionalized Isolute Silica.

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