Extraction of a range of immunosuppressants from whole blood using ISOLUTE SLE+ prior to LC-MS/MS analysis

Resource type:
Application note
Format:
pdf
Date of creation:
5 November 2017
Library code:
11399
ISOLUTE SLE+ Supported Liquid Extraction plates offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalyticalsample preparation, providing high analyte recoveries, no emulsion formation and significantly reduced sample preparation.
This application note describes the extraction of sirolimus, tacrolimus, everolimus and cyclosporin A from whole blood samples using supported liquid extraction prior to LC-MS/MS analysis.