Sensitive detection of nitrosamines for drug quality control using SICRIT soft ionization-MS
Resource type:
Application note
Format:
pdf
Date of creation:
23 February 2022
Library code:
13432
The presented data show sensitive detection of nitrosamine compounds by GC-SICRIT-MS. Furthermore, the superior ionization potential of SICRIT allows for analysis of NDMA impurites in valsartan drugs in one single run, which could not be realized with LC-MS methods. GC-SICRIT-MS has great potential for universal pharmaceutical quality control by significantly reducing costs and efforts in method development and routine analysis.
