SICRIT-HRMS for metabolic profiling through direct breath analysis

This application note demonstrates an easy extension of conventional capabilities for the SICRIT ionization source, coupled to a high-resolution MS instrument, through a metabolomic-based breath analysis and how groups of target masses can be isolated and analyzed for potential biomarker identification. Additionally, we can see the sensitivity and broad ionization capabilities of the source through a comparison of different subjects, where the subtle differences in everyone’s metabolic profile is given by the spectral distribution of metabolite density.