Physical stability of pharmaceutical dispersions

The world of drug delivery is getting more and more efficient every day with new forms of products, which are directly targeting the deficient organs. Dispersed systems such as emulsions (simple or multiple) or nanoparticle suspensions (metal oxides, etc.) are now widely used as drug carriers or nutritional solutions in this purpose. These new forms of products allow better targeting and assimilation for the patient, and give rise to new solutions for drug designers. However, the stability of these inherently unstable colloidal systems makes them complex to formulate and study.

Formulaction TURBISCAN enables to detect, qualify and quantify any destabilisation of drug dispersions from product development to quality control.

Applications include:

• Vaccines: kinetic of particles aggregation and sedimentation (proteins, metal oxides….)
• Skin lotions and creams: detection of coalescence and creaming up to 200 times faster than visual test
• Ophthalmic suspensions: study of the re-dispersion of active ingredient after storage
• Inhalers: study of particles aggregation & sedimentation in pressurized measurement cells