Purification of synthetic molecules and natural products by HPCCC

Dynamic Extractions High Performance Countercurrent Chromatography (HPCCC) finally allows to profit from the advantages of liquid-liquid chromatography

CCC machines were introduced in the early 1980s, they took many hours to perform a complete purification. The introduction by Dynamic Extractions of High Performance CCC has reduced separation time by a factor of 10 and made liquid-liquid chromatography accessible. Separation chemists can now take advantage of the power of using liquid stationary phases.

The key benefits of using a liquid, rather than a solid stationary phase can be summarised as follows:

• High loading capacity
• In HPCCC sample solubility is usually not an issue. The advantage of HPCCC is that the sample can be dissolved in either the mobile or the stationary phase with no impact on the quality of purification. On the contrary, sample solubility is often the limiting factor of any purification using a solid stationary phase.
• Ease of scale-up
• Total sample recovery
• Little or no sample preparation
• Low solvent consumption

HPCCC by Dynamic Extractions is the rebirth of liquid-liquid chromatography! HPCCC is especially useful for the purification of synthetic molecules and natural products at all scales, from analytical to industrial scale.