Extraction of synthetic cannabinoids (SPICE), opiates and benzodiazepine drugs from oral fluid using supported liquid extraction (SLE)

Drug of abuse testing is typically conducted using urine specimens from patients being screened for illicit drug use. While collection of urine is considered a relatively non-invasive drug testing action, it is not convenient for law enforcement to do in the field. The ability to collect an oral fluid sample in the field can be considered non-evasive and simple to implement. Currently there are oral fluid collection kits (e.g. Immunalysis Quantisal, Orasure Technologies Intercept) that facilitate the collection in easy to follow protocols. Oral fluid samples collected using standard collection kits can be qualitatively and quantitatively analyzed by LC-MS-MS, post extraction of the target analytes from the matrix. Drug analytes can be successfully extracted from oral fluid using supported liquid extraction (ISOLUTE SLE+), which offers an efficient alternative to traditional liquid-liquid extraction (LLE).

The extraction methodologies employed in this poster demonstrate the utility of supported liquid extraction as a viable extraction sorbent a broad range of drugs in complex matrices.