Characterization of tau protein aggregates with AF4 and UV-MALS-DLS
In this study, tau protein samples were analyzed by asymmetrical flow field-flow fractionation (AF4) coupled with UV/Vis, multi angle light scattering (MALS) and dynamic light scattering (DLS) detection to characterize 1) the protein monomer, 2) the protein fibril aggregate, and 3) the protein fibril aggregate after bath sonication.