Norlab

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Small molecules automated extraction from human breast milk using the Extrahera and the Evolute Express CX prior to LC-MS-MS analysis
Biotage developed an extraction protocol for 12 common drugs of abuse (DOA) to be detected in breast milk using mixed-mode polymeric cation exchange solid phase extraction (SPE). The Evolute Express CX extraction allowed for highly-sensitive detection of analytes. Extrahera, a bench top automated extraction system, provided minimal sample intervention and high throughput for the analysis of these DOA.

Determination of optimal sample size with microelution without dry down using SPE for a drugs of abuse panel
In this note, an extraction protocol using a 10 mg mixed-mode cation exchange sorbent (Evolute Express CX) was developed and various sample sizes were assessed to determine the optimal sample volume for a 98-compound DOA panel. A method involving microelution off of the sorbent requiring no evaporation or reconstitution steps were also developed.

Evolution of sample preparation: workflow simplification utilizing sample hold-up technology in forensic and clinical analyses
This note evaluates simplified sample preparation workflows using optimized sample hold-up technology allowing chemistry in-situ. Reduced labour, extraction complexity, processing time, solvent usage and resultant instrument contamination and downtime can offset upfront costs associated with sample preparation.

Evaluation of simplified workflow for drugs of abuse extraction from nail samples prior to LC-MS-MS analysis
This application demonstrates workflow advantages for fingernail analysis; multi-sample homogenization, extraction and analysis for a range of drugs of abuse.

Biotage TurboVap options after Dionex ASE extraction
This technical note helps the user decide which TurboVap model will best fit a laboratory's application.

ASE compatible TurboVap LV
The Biotage TurboVap LV is designed to accommodate the IChem vials from the Dionex ASE 200.

ASE Compatible TurboVap II
The Biotage TurboVap II is designed to accommodate the Dionex ASE 40 mL stemmed tubes.

Simplified sample preparation for low level determination of cannabis use from hair samples prior to LC-MS/MS analysis
This poster describes a simplified workflow for the low level analysis of cannabis from hair, utilizing bead based micro pulverization (MPE).

Extraction of THC and its metabolites from human hair using ISOLUTE SLE+ prior to UHPLC-MS/MS analysis
This application note describes a procedure for sample pre-treatment and extraction of THC and metabolites from human hair, using Biotage Lysera for matrix pulverization of the sample prior to clean up using ISOLUTE SLE+ supported liquid extraction.

Automated extraction of opiates from hydrolyzed and non-hydrolyzed urine using ISOLUTE SLE+ prior to GC/MS analysis
This application note describes the fully-automated extraction of opiates from acid-hydrolyzed urine and non-hydrolyzed urine prior to GC/MS analysis. The methods were automated using Biotage Extrahera configured for use with ISOLUTE SLE+ supported liquid extraction columns.

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