Optical rotation measurement for a small amount of sample

The optical rotation measurement is a common analytical method used for the evaluation of synthesized compounds and new compounds isolated and purified from natural products, while in most of the cases, the amount of compounds obtained from the synthesis for which many steps are required or target compounds obtained from valuable natural products is usually very small. Therefore, it is essential to enable the measurement of such sample with the amount as small as possible and a series of cells have been lined up. This report proves the optical rotation of the minimum 1 mL sample can be measured.