Norlab

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Effective extraction strategies for buprenorphine and norbuprenorphine in urine, oral fluid and whole blood using cation exchange solid phase extraction and supported liquid extraction prior to HPLC-MS/MS analysis
This poster demonstrates two fast and robust methods for the extraction of buprenorphine and norbuprenorphine in urine, oral fluid and whole blood.

Extraction of urinary hormone metabolites using supported liquid extraction prior to HPLC-MS/MS analysis
In this poster, Biotage demonstrates a rapid and reliable sample preparation method using support liquid extraction (SLE+) to extract a suite of 30 hormone analytes from a hydrolyzed urine matrix.

Optimisation of supported liquid extraction for the analysis of amphetamines in hair
This poster illustrates multiple benefits to laboratory workflow saving both worker hours and consumable costs, and that ISOLUTE SLE+ enables a fast, reliable protocol to extract amphetamines from hair matrix.

Assessment of solvent polarity upon drugs of abuse in oral fluids using supported liquid extraction prior to LC/MS analysis
34 compounds comprised of opioids, benzodiazepines and stimulants were examined.

Sample preparation strategies for urine panels with over 50 drugs and metabolites, analyzed by LC-MS/MS
Three sample preparation methodologies were evaluated for 52 drug analytes.

Drugs of abuse extraction from oral fluid using supported liquid extraction (SLE) following collection with NeoSal prior to GC/MS analysis
The drug suites included amphetamines and synthetic cathinones, barbiturates, benzodiazepines, cocaine, opiates, cannabinoids and synthetic cannabinoids.

Drugs of abuse extraction from whole blood using supported liquid extraction (SLE) and Extrahera automation prior to UPLC-MS/MS analysis
This poster discusses the potential for a single extraction protocol for various drugs of abuse classes prior to UPLC-MS/MS analysis.

Extraction of catecholamine acid metabolites from plasma prior to analysis using UHPLC-MS/MS
This poster presents optimization of the method development process to maximize analyte sensitivity in the extraction and quantitation of VMA, HVA and 5 HIAA metabolites from plasma. Parameters investigated include MRM transitions, chromatography and sample preparation protocols.

Comparison of sample preparation options for the extraction of a panel of endogenous steroids from serum prior to UHPLC-MS/MS analysis
This poster compares sample preparation options for the extraction of a panel of endogenous steroids from serum. LC-MS/MS parameters were investigated for increased sensitivity: MRM transitions, chromatography and mobile phase additives for use with positive and negative ionisation modes.

Extraction of tricyclic anti-depressants from plasma using ISOLUTE SLE+ supported liquid extraction plates
This application note describes the development of an automated procedure for high throughput supported liquid extraction of three tricyclic antidepressant drugs from human plasma, using the ISOLUTE SLE+ supported liquid extraction plate. Analyte recovery, along with the speed and efficiency are compared to traditional liquid-liquid extraction (LLE).

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