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Extraction of a drugs of abuse panel from oral fluid using ISOLUTE SLE+ after collection with the Intercept oral fluid drug test kit prior to UPLC-MS-MS analysis
An effective and efficient ISOLUTE SLE+ protocol optimized for the 1 mL capacity column format is described.

Extraction of a drugs of abuse panel from oral fluid using ISOLUTE SLE+ after collection with the Oral-Eze collection device prior to UPLC-MS/MS analysis
An effective and efficient ISOLUTE SLE+ protocol optimized for both 400 uL and 1 mL sample capacity column formats is described in this application note.

Extraction of MI from sun lotion using ISOLUTE SLE+ prior to GC/MS analysis
An effective and efficient ISOLUTE SLE+ protocol optimized for the 1 mL sample capacity column format is described.

Extraction of 11-nor-9-carboxy-tetrahydrocannabinol from hydrolyzed urine by ISOLUTE SLE+ prior to GC/MS analysis
The simple sample preparation procedure delivers clean extracts and analyte recoveries greater than 87% with RSDs lower than 10% for all analytes, and is optimized for use with 1 mL sample capacity ISOLUTE SLE+ columns.

Extraction of anabolic steroids from horse urine using ISOLUTE SLE+ prior to LC-MS/MS analysis
The method described in this application note achieves high reproducible analyte recoveries from both gelding and filly urine. Protocols for 48-well, 96-well plate and column formats are described.

Extraction of barbiturates from whole blood using ISOLUTE SLE+ prior to GC/MS analysis
ISOLUTE SLE+ columns with 1 mL sample capacity are used to extract whole blood samples following a straightforward sample dilution. No protein precipitation or other pre-treatment is required prior to sample loading.

Extraction of benzodiazepines from whole blood using ISOLUTE SLE+ prior to GC/MS analysis
ISOLUTE SLE+ columns with 1 mL sample capacity are used to extract whole blood samples following a straightforward sample dilution. No protein precipitation or other pre-treatment is required prior to sample loading.

Extraction of buprenorphine and norbuprenorphine from whole blood using ISOLUTE SLE+ Supported Liquid Extraction prior to LC-MS/MS analysis
ISOLUTE SLE+ Supported Liquid Extraction products offer an efficient alternative to traditional liquid-liquid extraction for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation and significantly reduced sample preparation time.

How to process ISOLUTE SLE+ plates and columns with Pressure+ 96 & 48 positive pressure manifolds
ISOLUTE SLE+ Supported Liquid Extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation and greatly matrix effects associated with biofluid analysis.

Biotage EVOLUTE advanced polymeric sorbents SPE columns and plates

EVOLUTE EXPRESS sample preparation products are advanced water-wettable polymer-based sorbents for extracting drugs from biological fluids. Developed specifically for analyte quantification by LC-MS/MS, EVOLUTE sorbents provide a highly effective solution to the problems of ion suppression and matrix effects from dirty extracts. These high performance products allow scientists to use generic methodologies to reduce method development time while producing clean extracts for a wide range of compounds.

EVOLUTE EXPRESS represents a leap forward in high throughput solid phase extraction. The EVOLUTE EXPRESS range of SPE columns and 96-well plates combine powerful EVOLUTE sorbent chemistry with innovative features that enhance productivity. With improved flow-through characteristics and by eliminating the need for conditioning and equilibration, samples can be prepared much faster using the simplified Load-Wash-Elute procedure

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